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PIRFENIDONE ESBRIET : Cost/Price, Dosage/Doses, Uses, Side Effects, Warnings etc. information

Generic PIRFENIDONE / Brand ESBRIET 200mg / 267mg / 400mg Tablet is a medicine prescribed for treating idiopathic pulmonary fibrosis. Pirfenidone / Esbriet medicine is classified as an antifibrotic medicine. Pirfenidone / Esbriet medication decreases swelling in the lungs and fibrosis (scarring). Breathing gets easier with the use of this Pirfenidone / Esbriet drug.

What are the international reference brand names of Generic drug Pirfenidone? The actual Generic Drug and Base Medicine PIRFENIDONE is sold internationally under the most common marketing brand(s) ESBRIET. See our lowest Pirfenidone Esbriet cost / prices at the top of this page.

What is the brief overview information on Generic Pirfenidone / Brand Esbriet ? Pirfenidone is a new drug that has the anti-fibrotic and anti-inflammatory properties which are mainly used to improve the working of the lungs in the case of Idiopathic Pulmonary Fibrosis also known as IPF.

What is the Branded Drug Esbriet / Generic Pirfenidone used for (Indications) ? Pirfenidone is recommended by the doctors to treat IPF or Idiopathic Pulmonary Fibrosis. This is a serious irreversible disease in which remarkable declination of lung function is noticed. The origin of the cause of the lungs scarring is unknown. It not known how exactly the mechanism of Pirfenidone works. Pirfenidone may help in reducing the lungs fibrosis by lowering the release of the level or the work of the naturally occurring substances of specific growth in the human body.

When should Esbriet / Pirfenidone medication not to be used (Contraindications) ? Pirfenidone is restricted in patients who are: • At the last stage of renal disease and require dialysis. • Suffering from severe damage or impairment of the liver. It is also risky in patients who are under Fluvoxamine treatment.

What’s the prescribed Pirfenidone Esbriet dosage / dosing requirement? • The suggested adult dosage for regular maintenance is 801mg. The patient may take each capsule of 267mg thrice a day with food. • The highest daily dose of the drug should not be more than 2403mg. The initial dose of the drug can be started as per followings to treat idiopathic pulmonary fibrosis: In the first week - One capsule every day In the second week - 2 capsules every day From 15th day - 3 capsules every day • If the patients miss Pirfenidone dose for two weeks or more, then the treatment should be restarted with an initial schedule of 14 days. The full maintenance dose of the drug should be scheduled from 15th day. • If the patients miss the dose for less than two weeks, then the dose can be continued until it gets interrupted. The patients should never intake two doses of the drug at a time. The doses for a patient should never be more than three in a day.

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What are the Brand Esbriet / Generic Pirfenidone drug / pills uses? • Pirfenidone is available in the form of a capsule that should be taken orally. • The patient should take the dose with food in order to avoid any gastric discomfort. • Patients should fix a time and take the everyday dose at the same time.

What are the Esbriet Pirfenidone warnings and precautions before use ? • Patients under the Pirfenidone therapy, may develop increased liver enzymes level. So it is important to monitor the levels for adjusting the temporary dosage or stop the therapy permanently. • The possibilities of rashes and tanning beds, sensitivity to sunlight, and other fluorescent lamps are high in this therapy. So, you should ignore direct exposure to the sunlight and go out with the sunscreen (SPF- sun protection factor- 50 or even higher) protection, sunglasses, and protective clothes. • The safety measurement for the children under Pirfenidone therapy is unknown.

What are Pirfenidone Esbriet side effects ? • Gastrointestinal: Nausea, gastritis, vomiting, GERD (gastro-oesophageal reflux), lack of appetite, abdominal pain, indigestion, abdominal distension. • Skin: Photosensitivity, itching, rash, and dryness of the skin. • Central Nervous System: Insomnia, dizziness, and fatigue • Respiratory: Upper respiratory infections and sinusitis • Others: Joint pain, increased liver enzymes, weight loss

What are the other Brand name Esbriet / Generic Pirfenidone Esbriet warnings and precautions? • Cigarette smoking under this therapy should not be continued because smoking increases the chance of drug clearance from the body, and it leads to low drug effectiveness. • The calorie intake of the patient should be increased especially for those who have lost their weight due to having Pirfenidone.

What are Pirfenidone Esbriet medication interactions with other drugs? Pirfenidone toxicity may rise if it is taken with the drugs like the followings. Thus the below mentioned combination of these drugs with Pirfenidone should not be administrated. • Antidepressants like Fluoxetine, Fluvoxamine, and Paroxetine • Plasma level circulation of antibiotics like Chloramphenicol and Ciprofloxacin Pirfenidone may become low with drugs like Omeprazole.

What are the storage conditions of Brand Name Esbriet / Generic Drug Pirfenidone? • Preserve the medicine in a container which is tightly closable. • Discard the damaged or expired medicine safely.

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The above information has been summarized from U.S. NATIONAL LIBRARY OF MEDICINE , is intended only to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

Esbriet - Pirfenidone : Package Insert / Prescribing Information Leaflet, Medication Guides & Instructions for Use

Patient Package Inserts (PPI), Medication Guides (MG), and Instructions for Use (IFU) are paper handouts that come with many prescription medicines. The guides address issues that are specific to particular drugs and drug classes, and they contain FDA-approved information that can help patients use the medicine safe and effectively and try to avoid serious adverse events. Not all medicines have patient information and if you have questions about your medicines you should always talk with your Healthcare Provider or Pharmacist.

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