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MACITENTAN / OPSUMIT 10 MG TABLETS

Macitentan 10 mg Tablets ( Generic of Opsumit )

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Opsumit 10 mg Tablets of Actelion ( Brand Drug )

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MACITENTAN OPSUMIT : Cost/Price, Dosage/Doses, Uses, Side Effects, Warnings etc. information

Generic MACITENTAN / Brand OPSUMIT 10mg Tablet is used for treating increased blood pressure in the lungs (pulmonary arterial hypertension). Macitentan / Opsumit medicine works by blocking the effects of endothelin-1, which helps in reducing the blood pressure in the lungs and decreases the risk of the symptoms getting worse and hospitalization due to the disease.

What are the international reference brand names of Generic drug Macitentan? The actual Generic Drug and Base Medicine MACITENTAN is sold internationally under the most common marketing brand(s) OPSUMIT. See our lowest Macitentan Opsumit cost / prices at the top of this page.

What is the brief overview information on Generic Macitentan / Brand Opsumit ? Macitentan falls under the endothelin receptor antagonists class of medication, which is prescribed by a healthcare professional in combination with other medicine or alone to treat PAH (Pulmonary Arterial Hypertension). Pulmonary Arterial Hypertension or PAH is a condition that is characterized by high blood pressure in the blood vessels of the lungs that lead to the heart. In case of pulmonary hypertension, these blood vessels get narrowed or blocked, which makes it more difficult for the blood to flow through the lungs thus the heart has to work harder to pump blood through the lungs. This medicine acts by reducing the blood pressure in your lungs and allowing your heart to pump more effectively and efficiently.

What is the Branded Drug Opsumit / Generic Macitentan used for (Indications) ? Information not available, sorry.

When should Opsumit / Macitentan medication not to be used (Contraindications) ? It is advised to not to take this medicine if you - • have ay allergy in MACITENTAN or any components of the medication • are planning to get pregnant or already pregnant • are breastfeeding.

What’s the prescribed Macitentan Opsumit dosage / dosing requirement? Information not available, sorry.

What to do if Generic Macitentan / Brand Opsumit dosage is missed ?

What are the Brand Opsumit / Generic Macitentan drug / pills uses? For adults, the advised dose of this medicine is 10 mg that is to be taken one time daily either with food or without food. This medication should not be crushed, broken or chewed while consuming. This medicine is to be swallowed as a whole with water. Please take the prescribed dose of the medication.

What are the Opsumit Macitentan warnings and precautions before use ? Before you start taking this medication, you have to positively notify your physician of any clinical conditions or allergies you are experiencing, under any other medications, you are pregnant or lactating, and any other noteworthy details about your health. The doctor may alter the use of this medicine, keeping in mind these factors. Anemia: If you experience any symptoms of low red blood cell count (anemia) like feeling unusually tired or pale skin, shortness of breath while taking this medicine it is advised to contact your doctor at earliest as Macitentan is known to cause low levels of red blood cells. Kidney function: Patients with known kidney diseases or reduced kidney function may experience certain side effects while taking this medicine. It is advised to discuss with your doctor every possible factor like how this medicine may affect your existing clinical condition, how your current medical condition will have an effect on the dose and effectiveness of the medication, or any regular monitoring of vital parameters are needed or not if you have a reduced kidney function, before taking this medicine. Liver function: As MACITENTAN may reduce liver function so if you have liver problems before taking this medicine then discuss with your doctor every possible factor like how this medicine may affect your existing clinical condition, how your current medical condition will have an effect on the dose and effectiveness of the medication, or any regular monitoring of vital parameters are needed or not. Your general practitioner may test your liver function on a regular basis while you are taking this drug. This medicine is not advised to be used by people who have severely reduced liver function. Pregnancy: This medication is harmful to both the baby and the mother. This drug may harm or cause death to the developing baby and mother if it is taken in the pregnancy period. Women are advised to avoid pregnancy while taking Macitentan or for at least a month after discontinuing the medication. Your physician may regularly perform pregnancy tests while you are taking this medicine to ensure the safety of taking this drug. Women who are planning to get pregnant should avoid taking this medicine until the chance of pregnancy is not ruled out. If by any chance you become pregnant while taking this medication, seek medical help at earliest. Breastfeeding: There is no proven evidence that if Macitentan gets mixed in the mother’s milk. This medicine may affect your baby so it is advised to take medical help if you are a lactating woman and are consuming this medicine. Women are advised to avoid breastfeeding while taking this medication. Children: For children who are less than 18 years of age, the safety and effectiveness of using this medicine have not been established yet.

What are Macitentan Opsumit side effects ? At least 1% of the total people who are taking this medicine have reported experiencing the following side effects. Several of the below mentioned side effects are manageable, while some may vanish on their own over a period of time. It is advised to consult your physician if you experience any of these side effects that are severe and bothering you. Your pharmacist may also be able to advise certain techniques of managing side effects. • Headache • persistent cough • stuffy nose • flu-like symptoms (fever, cough, sudden lack of energy, sore throat) Consult your doctor at the earliest if any of the following side effects take place: • signs of a serious allergic reaction (e.g. difficulty breathing, nausea and vomiting, abdominal cramps, or swelling of the throat and face) • signs of reduced red blood cells or anemia (e.g. pale skin, dizziness, shortness of breath, unusual tiredness or weakness) • signs of liver problems (e.g. , pale stools, dark urine, nausea, vomiting, diarrhea, yellowing of the skin or whites of the eyes ,loss of appetite, loss of weight) • symptoms of a urinary tract infection (UTI) (e.g. frequent urge to urinate, urgency to urinate ,painful urination, pressure in the lower pelvis, fever) • irritation of the airways (bronchitis) It is advised to immediately discontinue this medicine and consult a physician if any of the above mentioned side effects occur.

What are the other Brand name Opsumit / Generic Macitentan Opsumit warnings and precautions? Information not available, sorry.

What are Macitentan Opsumit medication interactions with other drugs? MACITENTAN may be certain interaction with the below mentioned drugs: • "azole" antifungals (e.g., itraconazole, ketoconazole, voriconazole) • aprepitant • bosentan • boceprevir • cyclosporine • conivaptan • calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil) • carbamazepine • dronedarone • deferasirox • enzalutamide • grapefruit juice • HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir) • HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delavirdine, efavirenz, etravirine, nevirapine) • macrolide antibiotics (e.g., clarithromycin, erythromycin) • modafinil • mitotane • mifepristone • metronidazole • nefazodone • phenytoin • phenobarbital • primidone • certain protein kinase inhibitors (e.g., crizotinib, dabrafenib, dasatinib, imatinib) • rifampin • rifabutin • stiripentol • St. John's wort • siltuximab • simeprevir • tocilizumab • telaprevir If you are under the medication of any of the above mentioned drugs, then it is advised to consult your medical professional or chemist. Depending on your specific conditions, your general practitioner may want you to: • discontinue taking one of the medicines, • prescribe any alternate medicine, • change the dose and how you are taking one or both of the medications, or • leave everything as it is.

What are the storage conditions of Brand Name Opsumit / Generic Drug Macitentan? Information not available, sorry.

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The above information has been summarized from U.S. NATIONAL LIBRARY OF MEDICINE , is intended only to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

Opsumit - Macitentan : Package Insert / Prescribing Information Leaflet, Medication Guides & Instructions for Use

Patient Package Inserts (PPI), Medication Guides (MG), and Instructions for Use (IFU) are paper handouts that come with many prescription medicines. The guides address issues that are specific to particular drugs and drug classes, and they contain FDA-approved information that can help patients use the medicine safe and effectively and try to avoid serious adverse events. Not all medicines have patient information and if you have questions about your medicines you should always talk with your Healthcare Provider or Pharmacist.

Medication Guides are developed by the manufacturer, approved by the FDA, and required to be given to consumers each time the medication is dispensed. You may see a printable pdf copy of the Medication Guide / Patient Information Leaflet of Opsumit - Macitentan in English

Patient Information Videos on Opsumit – Macitentan

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The Impact of Macitentan on Functional Class
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