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BARICITINIB OLUMIANT : Cost/Price, Dosage/Doses, Uses, Side Effects, Warnings etc. information

Generic BARICITINIB / Brand OLUMIANT 2mg / 4mg Tablet is used for treating rheumatoid arthritis. Baricitinib / Olumiant medicine is classified as a Janus kinase inhibitor that blocks the activity of Janus kinase, an enzyme. Baricitinib / Olumiant medication lowers the inflammation and damaging of the joints in rheumatoid arthritis.

What are the international reference brand names of Generic drug Baricitinib? The actual Generic Drug and Base Medicine BARICITINIB is sold internationally under the most common marketing brand(s) OLUMIANT. See our lowest Baricitinib Olumiant cost / prices at the top of this page.

What is the brief overview information on Generic Baricitinib / Brand Olumiant ? The FDA approved Baricitinib tablets on May 31, 2018, for oral use only. The tablets are used in patients with rheumatoid arthritis. This medicine is specifically for patients who failed to show a response to other medications.

What is the Branded Drug Olumiant / Generic Baricitinib used for (Indications) ? Baricitinib, in the form of tablets, is used for the treatment in adults who suffer from moderate to acute rheumatoid arthritis. Baricitinib acts as a Janus kinase (JAK) inhibitor that is responsible for activating the pro-inflammatory mediators and molecules, which eventually leads to autoimmune disorders. Baricitinib can be administered directly or together with any disease-modifying antirheumatic drugs (DMARDs) like methotrexate and also this medication is for patients who do not respond to several tumour necrosis factors (TNF) antagonist therapies. On Feb 13, 2017, Baricitinib tablets got approval from the European medicines agency (EMA) to be used across the EU.

When should Olumiant / Baricitinib medication not to be used (Contraindications) ? It is advised not to use Baricitinib for patients with • Allergy in this medication • Duringpregnancy or breastfeeding • Previous instances of active or acute infections like Tuberculosis • Blood diseases like Anemia or low lymphocyte/neutrophil count • Acute liver or kidney disorder It is advised not to administer Baricitinib tablets to children under 18 years of age, since the potency and efficacy of the medication for children is yet to be studied. Special care must be taken while handling patients with • Previous cases of cancer or any kind of malignancy • Diverticulitis or Peptic ulcer • Showing blood clots (Pulmonary embolism, Deep vein thrombosis)

What’s the prescribed Baricitinib Olumiant dosage / dosing requirement? • It is recommended that you take 2mg of Baricitinib per day • You can increase the dose to a maximum of 4mg but should reduce it to 2mg, once the condition improves • It is advised to consider changes and adjustments in the dosage of Baricitinib for patients suffering from acute infections of blood diseases like very low count of lymphocytes, neutrophils, and haemoglobin. • In case infection occurs, the treatment must be stopped immediately and should not be resumed until the infection comes under control.

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What are the Brand Olumiant / Generic Baricitinib drug / pills uses? • Baricitinib, in the form of tablets, can be taken orally via mouth with food or in an empty stomach. • Patients can take Baricitinib tablets, anytime during the day, but should regularly take it at the same time each day. • It is advised to consume the entire tablet at once, with plenty of water.

What are the Olumiant Baricitinib warnings and precautions before use ? • Do not take any other vaccines while undergoing Baricitinib treatment since Baricitinib can reduce the impact of other vaccines. • During Baricitinib therapy patients have reported abrupt levels of liver enzymes and lipid profiles like low-density lipoproteins and total cholesterol. Thus, patients are advised to check their lipid parameters, once every 12 weeks, while undergoing the Baricitinib treatment. • If you observe reduced lymphocytes, hemoglobin, or neutrophils levels while under this medication, then adjust and modify the dose accordingly. In case there is a significant drop in the levels, stop the Baricitinib treatment immediately, and focus on blood disorders. • During Baricitinib treatment, if someone experiences pain in the stomach or any similar symptoms, then immediately check for gastrointestinal perforations and take actions to treat them. • Patients who are prone to skin cancer or have had major medical issues in the past must go for skin checkups periodically while undergoing Baricitinib treatment. This would help in the detection and early treatment of skin cancers like non-melanoma skin cancer (NMSC). • Patients must be examined for viral hepatitis before the Baricitinib treatment is started since Baricitinib can reactivate the virus. • If a patient is seen developing herpes zoster, while under the Baricitinib treatment, then the treatment must be stopped immediately. • Before starting the Baricitinib treatment, screening for active or latent tuberculosis (TB) must be done for patients and in case of any positive TB cases, treat it first with antimycobacterial therapy. • During the Baricitinib treatment, regularly examine patients for any signs of tuberculosis, since the treatment can trigger tuberculosis, even though the patient tested negative before the treatment.

What are Baricitinib Olumiant side effects ? • Gastrointestinal side effects include vomiting tendency, pain in the stomach, ulcer, high blood cholesterol levels, infectious diarrhea, low-density lipoproteins (LDL), and unusual liver enzymes (AST (SGOT) and ALT (SGPT)) levels. • Respiratory side effects include sore throat, nose blockage, sinusitis, common cold, tonsil swellings, and pharynx. • Side effects for blood include reduced levels of hemoglobin, neutrophils, and lymphocytes, and the presence of blood clots. • Side effects in the kidney include infections in the urinary tract like pyelonephritis and cystitis. • Other side effects include viral infections like herpes zoster or herpes simplex.

What are the other Brand name Olumiant / Generic Baricitinib Olumiant warnings and precautions? • In case any infection is observed during the Baricitinib treatment, inform the doctor immediately so that the treatment can be kept on hold till the infection is neutralized. • You should not take Baricitinib tablets other than the prescribed reasons and never advise or recommend Baricitinib to any other patient who exhibits similar symptoms.

What are Baricitinib Olumiant medication interactions with other drugs? • Baricitinib should not be administered with JAK inhibitors (like Tofacitinib and Ruxolitinib) or Immunosuppressant drugs (like Azathioprine, Cyclosporine, and Tacrolimus), otherwise, it might lead to additive immune suppression. • You must avoid ibuprofen, diclofenac, or any other Non-steroidal anti-inflammatory drugs with Baricitinib since the former drugs can increase Baricitinib levels inside the body ultimately increasing the chances of gastric perforation. • Other drugs that should not be taken or if necessary to be taken then it should be taken under medical supervision, along with Baricitinib are: o Leflunomide or teriflunomide o Probenecid o Corticosteroids

What are the storage conditions of Brand Name Olumiant / Generic Drug Baricitinib? • Store Baricitinib tablets at room temperature (at 20°C to 25°C). • Do not expose the tablets to excessive heat and moisture. • Keep the Baricitinib tablets away from children

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The above information has been summarized from U.S. NATIONAL LIBRARY OF MEDICINE , is intended only to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

Olumiant - Baricitinib : Package Insert / Prescribing Information Leaflet, Medication Guides & Instructions for Use

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